Journal: Ophthalmology. Retina

Article Title: Longitudinal analysis of the retina and choroid in cognitively normal individuals at higher genetic risk for Alzheimer disease

doi: 10.1016/j.oret.2022.03.001

Figure Lengend Snippet: Within-group retinal and choroidal imaging parameters of subjects imaged longitudinally

Article Snippet: There was no difference in rate of change in any peripapillary OCTA measure ( ). table ft1 table-wrap mode="anchored" t5 Table 6: caption a7 APOE ε4+ N=134 eyes (71 subjects) APOE ε4− N=149 eyes (78 subjects) P-value a Mean change per year (SD) Equivalent % change/year Mean change per year (SD) Equivalent % change/year OCT parameters Average CST, microns −0.138 (3.107) −0.05% −0.657 (2.585) −0.24% 0.325 Average GC-IPL thickness, microns −0.158 (1.332) −0.21% 0.128 (1.219) 0.17% 0.099 Average RNFL thickness, microns 0.104 (1.571) 0.12% 0.250 (1.815) 0.29% 0.420 Choroidal parameters Total choroidal area, units 2 b 0.023 (0.254) 0.48% −0.024 (0.250) −0.51% 0.303 Luminal area, units 2 b 0.013 (0.164) 0.40% −0.017 (0.159) −0.53% 0.287 Choroidal vascularity index, % < −0.0005 (0.006) < −0.07% < −0.0005 (0.007) < −0.09% 0.874 OCTA parameters FAZ area, mm 2 0.003 (0.016) 1.25% 0.002 (0.164) 0.87% 0.722 PD (3mm ETDRS circle) 0.002 (0.016) 0.56% 0.002 (0.015) 0.56% 0.916 PD (3mm ETDRS ring) 0.002 (0.016) 0.53% 0.002 (0.015) 0.53% 0.955 VD (3mm ETDRS circle), mm −1 0.012 (0.910) 0.06% 0.006 (0.876) 0.03% 0.907 VD (3mm ETDRS ring), mm −1 0.023 (0.939) 0.11% 0.014 (0.903) 0.07% 0.907 PD (6mm ETDRS circle) −0.001 (0.018) −0.23% < −0.0005 (0.015) < −0.11% 0.723 PD (6mm ETDRS outer ring) −0.002 (0.017) −0.44% < −0.0005 (0.016) < −0.11% 0.406 PD (6mm ETDRS inner ring) 0.001 (0.024) 0.23% 0.001 (0.018) 0.23% 0.784 VD (6mm ETDRS circle), mm −1 −0.070 (0.677) −0.39% −0.054 (0.599) −0.30% 0.782 VD (6mm ETDRS outer ring), mm −1 −0.095 (0.637) −0.53% −0.054 (0.625) −0.30% 0.525 VD (6mm ETDRS inner ring), mm −1 −0.002 (0.919) −0.01% −0.048 (0.704) −0.26% 0.644 Peripapillary OCTA parameters, mean (SD) CPD (average), % −0.193 (0.679) −0.44% −0.149 (0.593) −0.34% 0.855 CPD (superior), % 0.028 (1.026) 0.07% 0.002 (0.833) 0.00% 0.505 CPD (nasal), % −0.390 (1.162) −0.92% −0.277 (0.993) −0.65% 0.637 CPD (inferior), % 0.176 (0.913) 0.39% 0.211 (0.797) 0.48% 0.758 CPD (temporal), % −0.486 (0.881) −1.07% −0.473 (0.986) −1.04% 0.884 CFI (average) −0.015 (0.021) −3.75% −0.010 (0.020) −2.44% 0.305 CFI (superior) −0.007 (0.016) −1.71% −0.005 (0.014) −1.22% 0.573 CFI (nasal) −0.020 (0.028) −5.13% −0.015 (0.027) −3.75% 0.552 CFI (inferior) −0.007 (0.014) −1.71% −0.003 (0.013) −0.71% 0.211 CFI (temporal) −0.024 (0.030) −6.00% −0.015 (0.030) −3.57% 0.161 Open in a separate window CST=central subfield thickness, GC-IPL=ganglion cell-inner plexiform layer, RNFL=retinal nerve fiber layer, FAZ=foveal avascular zone, PD=perfusion density, VD=vessel density, ETDRS=Early Treatment Diabetic Retinopathy Study, CPD=capillary perfusion density, CFI=capillary flux index. a P-values based on generalized estimating equations (GEE) model score statistic for testing differences among and between means.

Techniques: Imaging

Journal: Ophthalmology. Retina

Article Title: Longitudinal analysis of the retina and choroid in cognitively normal individuals at higher genetic risk for Alzheimer disease

doi: 10.1016/j.oret.2022.03.001

Figure Lengend Snippet: Rate of change in retinal and choroidal imaging parameters

Article Snippet: There was no difference in rate of change in any peripapillary OCTA measure ( ). table ft1 table-wrap mode="anchored" t5 Table 6: caption a7 APOE ε4+ N=134 eyes (71 subjects) APOE ε4− N=149 eyes (78 subjects) P-value a Mean change per year (SD) Equivalent % change/year Mean change per year (SD) Equivalent % change/year OCT parameters Average CST, microns −0.138 (3.107) −0.05% −0.657 (2.585) −0.24% 0.325 Average GC-IPL thickness, microns −0.158 (1.332) −0.21% 0.128 (1.219) 0.17% 0.099 Average RNFL thickness, microns 0.104 (1.571) 0.12% 0.250 (1.815) 0.29% 0.420 Choroidal parameters Total choroidal area, units 2 b 0.023 (0.254) 0.48% −0.024 (0.250) −0.51% 0.303 Luminal area, units 2 b 0.013 (0.164) 0.40% −0.017 (0.159) −0.53% 0.287 Choroidal vascularity index, % < −0.0005 (0.006) < −0.07% < −0.0005 (0.007) < −0.09% 0.874 OCTA parameters FAZ area, mm 2 0.003 (0.016) 1.25% 0.002 (0.164) 0.87% 0.722 PD (3mm ETDRS circle) 0.002 (0.016) 0.56% 0.002 (0.015) 0.56% 0.916 PD (3mm ETDRS ring) 0.002 (0.016) 0.53% 0.002 (0.015) 0.53% 0.955 VD (3mm ETDRS circle), mm −1 0.012 (0.910) 0.06% 0.006 (0.876) 0.03% 0.907 VD (3mm ETDRS ring), mm −1 0.023 (0.939) 0.11% 0.014 (0.903) 0.07% 0.907 PD (6mm ETDRS circle) −0.001 (0.018) −0.23% < −0.0005 (0.015) < −0.11% 0.723 PD (6mm ETDRS outer ring) −0.002 (0.017) −0.44% < −0.0005 (0.016) < −0.11% 0.406 PD (6mm ETDRS inner ring) 0.001 (0.024) 0.23% 0.001 (0.018) 0.23% 0.784 VD (6mm ETDRS circle), mm −1 −0.070 (0.677) −0.39% −0.054 (0.599) −0.30% 0.782 VD (6mm ETDRS outer ring), mm −1 −0.095 (0.637) −0.53% −0.054 (0.625) −0.30% 0.525 VD (6mm ETDRS inner ring), mm −1 −0.002 (0.919) −0.01% −0.048 (0.704) −0.26% 0.644 Peripapillary OCTA parameters, mean (SD) CPD (average), % −0.193 (0.679) −0.44% −0.149 (0.593) −0.34% 0.855 CPD (superior), % 0.028 (1.026) 0.07% 0.002 (0.833) 0.00% 0.505 CPD (nasal), % −0.390 (1.162) −0.92% −0.277 (0.993) −0.65% 0.637 CPD (inferior), % 0.176 (0.913) 0.39% 0.211 (0.797) 0.48% 0.758 CPD (temporal), % −0.486 (0.881) −1.07% −0.473 (0.986) −1.04% 0.884 CFI (average) −0.015 (0.021) −3.75% −0.010 (0.020) −2.44% 0.305 CFI (superior) −0.007 (0.016) −1.71% −0.005 (0.014) −1.22% 0.573 CFI (nasal) −0.020 (0.028) −5.13% −0.015 (0.027) −3.75% 0.552 CFI (inferior) −0.007 (0.014) −1.71% −0.003 (0.013) −0.71% 0.211 CFI (temporal) −0.024 (0.030) −6.00% −0.015 (0.030) −3.57% 0.161 Open in a separate window CST=central subfield thickness, GC-IPL=ganglion cell-inner plexiform layer, RNFL=retinal nerve fiber layer, FAZ=foveal avascular zone, PD=perfusion density, VD=vessel density, ETDRS=Early Treatment Diabetic Retinopathy Study, CPD=capillary perfusion density, CFI=capillary flux index. a P-values based on generalized estimating equations (GEE) model score statistic for testing differences among and between means.

Techniques: Imaging

Journal: Osteoarthritis and Cartilage Open

Article Title: Associations between changes in leg extensor muscle power and physical function after supervised exercise in patients with hip osteoarthritis. Secondary analysis from the hip booster trial

doi: 10.1016/j.ocarto.2024.100523

Figure Lengend Snippet: Characteristics of included participants at baseline.

Article Snippet: We hypothesized, that (1) ΔLEP is associated with changes in performance-based physical function (30s-CST, 9step-TSCT and 40m-FPWT); (2) changes in ΔLEP are associated with changes in patient-reported measures of physical function (Activities of Daily Life (ADL) Function and Sport and Recreation function subscales of the Hip disability and Osteoarthritis Outcomes Score (HOOS) questionnaire); (3) ΔLEP will explain a larger part of the differences observed in physical function after PRT compared to after NEMEX defined by greater regression coefficients.

Techniques: Injection, Activity Assay, Functional Assay

Journal: Osteoarthritis and Cartilage Open

Article Title: Associations between changes in leg extensor muscle power and physical function after supervised exercise in patients with hip osteoarthritis. Secondary analysis from the hip booster trial

doi: 10.1016/j.ocarto.2024.100523

Figure Lengend Snippet: Changes in leg extensor muscle power and physical function for participants included in crude analyses after 12 weeks of progressive resistance training or neuromuscular exercise. On the right is the minimal difference in leg extensor muscle power that is associated with a minimal important difference in the measure of physical function. Minimal important differences were estimated as part of the primary paper by an anchor-based method.

Article Snippet: We hypothesized, that (1) ΔLEP is associated with changes in performance-based physical function (30s-CST, 9step-TSCT and 40m-FPWT); (2) changes in ΔLEP are associated with changes in patient-reported measures of physical function (Activities of Daily Life (ADL) Function and Sport and Recreation function subscales of the Hip disability and Osteoarthritis Outcomes Score (HOOS) questionnaire); (3) ΔLEP will explain a larger part of the differences observed in physical function after PRT compared to after NEMEX defined by greater regression coefficients.

Techniques: Functional Assay